Non-Clostridium difficile pseudomembranous colitis responding to both vancomycin and metronidazole. ?

Pseudomembranous colitis due to Clostridium difficile.

1. Department of Radiology, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey Background: A 25-year-old man was treated with ampicillin for acute tooth inflammation. After five days, he presented to the emergency department with intermittent abdominal pain especially at the right lower and left upper quadrant, bloody diarrhea, fever and nausea. Physical examination revealed diff...

Pseudomembranous Colitis: Not Always Caused by Clostridium difficile

Although classically pseudomembranous colitis is caused by Clostridium difficile, it can result from several etiologies. Certain medications, chemical injury, collagenous colitis, inflammatory bowel disease, ischemia, and other infectious pathogens can reportedly cause mucosal injury and subsequent pseudomembrane formation. We present the case of a middle-aged woman with vascular disease who wa...

Nitazoxanide versus metronidazole for Clostridium difficile-associated colitis.

To the Editor—Reports of increased incidence and severity of Clostridium difficile–associated colitis have stimulated interest in the search for additional treatment options for this clinical problem. Musher et al. [1] recently reported the results of a noninferiority study that compared metronidazole with nitazoxanide for the treatment of C. difficile colitis. The authors concluded that “nitaz...

Comparison of Fidaxomicin and Vancomycin for Recurrent Clostridium difficile Colitis

Prospective study of oral teicoplanin versus oral vancomycin for therapy of pseudomembranous colitis and Clostridium difficile-associated diarrhea.

A prospective, randomized study comparing oral teicoplanin with oral vancomycin in the treatment of pseudomembranous colitis (PMC) and Clostridium difficile-associated diarrhea (CDAD) was performed. Teicoplanin was administered at a dosage of 100 mg twice a day for 10 days, and vancomycin was administered at a dosage of 500 mg four times a day for 10 days. CDAD was diagnosed by demonstrating bo...